TY - JOUR T1 - Nicotinamide Phosphoribosyl Transferase a Reliable Marker of Progression in Cervical Dysplasia JF - Anticancer Research JO - Anticancer Res SP - 4821 LP - 4825 VL - 37 IS - 9 AU - MOIZ VORA AU - LUBNA A. ALATTIA AU - JUNAID ANSARI AU - MENCHU ONG AU - JAMES COTELINGAM AU - DOMENICO COPPOLA AU - RODNEY SHACKELFORD Y1 - 2017/09/01 UR - http://ar.iiarjournals.org/content/37/9/4821.abstract N2 - Background/Aim: Nicotinamide phosphoribosyl transferase (Nampt) catalyses the rate-limiting step of the mammalian nicotinamide adenine dinucleotide (NAD) salvage pathway. Nampt is highly expressed in several epithelial and mesenchymal neoplasms, where is promotes cell-cycle progression ans chemotherapy resistance. To our knowledge, alterations in Nampt expression have not been examined in cervical intraepithelial neoplasia (CIN) or squamous cell carcinoma (SCC). Materials and Methods: We performed immunohistochemical analysis for Nampt using tissue microarrays on 14 samples of benign cervical squamous epithelium and 15 CIN I, 15 CIN II, and 13 samples of CIN III. The SCCs included 5 low-grade, 67 intermediate-grade, and 81 high-grade tumors. Results: Nampt levels increased with increased CIN grades were compared to benign cervical squamous epithelium. Similarly, Nampt levels increased with increasing SCC grade. Conclusion: Nampt expression is a reliable marker of progression in cervical dysplasia and SCC. ER -