TY - JOUR T1 - Colorectal Carcinogenesis: Role of Oxidative Stress and Antioxidants JF - Anticancer Research JO - Anticancer Res SP - 4759 LP - 4766 VL - 37 IS - 9 AU - FRANCESCO CARINI AU - MARGHERITA MAZZOLA AU - FRANCESCA RAPPA AU - ABDO JURJUS AU - ALICE GERGES GEAGEA AU - SAHAR AL KATTAR AU - TAREK BOU-ASSI AU - ROSALYN JURJUS AU - PROVVIDENZA DAMIANI AU - ANGELO LEONE AU - GIOVANNI TOMASELLO Y1 - 2017/09/01 UR - http://ar.iiarjournals.org/content/37/9/4759.abstract N2 - One of the contributory causes of colon cancer is the negative effect of reactive oxygen species on DNA repair mechanisms. Currently, there is a growing support for the concept that oxidative stress may be an important etiological factor for carcinogenesis. The purpose of this review is to elucidate the role of oxidative stress in promoting colorectal carcinogenesis and to highlight the potential protective role of antioxidants. Several studies have documented the importance of antioxidants in countering oxidative stress and preventing colorectal carcinogenesis. However, there are conflicting data in the literature concerning its proper use in humans, since these studies did not yield definitive results and were performed mostly in vitro on cell populations, or in vivo in experimental animal models. ER -