RT Journal Article SR Electronic T1 Immediate and Long-term Results of Radiofrequency Ablation for Colorectal Liver Metastases JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6489 OP 6494 VO 37 IS 11 A1 CIPRIAN CIRIMBEI A1 VLAD ROTARU A1 ELENA CHITORAN A1 OANA PAVALEANU A1 SIMONA ELENA CIRIMBEI YR 2017 UL http://ar.iiarjournals.org/content/37/11/6489.abstract AB Background/Aim: Radiofrequency ablation (RFA) of colorectal liver metastases (CRLMs) is a method developed in the last 15 years. It provides an acceptable control of the malignant process with lower risks compared to surgical resection. The aim of the study was to assess immediate and long-term results, including recurrence, survival, morbidity/mortality rates after RFA. Patients and Methods: Sixty-two cases with CRLMs were treated by RFA during open surgery (89 lesions). Patients were followed-up for a minimum of 36 months, with assessment of recurrences and survival rates at 1, 2 and 3 years, using computed tomography (CT) scan, contrast-enhanced ultrasound and tumor markers (carcinoembryonoc antigen, carbohydrate antigen-19.9). Results: Local relapses, recurrences in other areas and survival rates at 1, 2 and 3 years suggest acceptable values comparative with liver resections in the first 2-3 years and demonstrated long-term limitations, despite the use of adjuvant chemotherapy. Major postoperative negative prognostic factors are tumor multicentricity and tumor's dimensions over 5 cm. Conclusion: RFA of CRLMs is a safe procedure with low rates of local relapses and recurrences, as well as acceptable survival rates, in the first 24-36 months post-procedure. It is recommended for patients with no indications for liver resection or having major resection risks.