RT Journal Article
SR Electronic
T1 Perioperative Administration of Traditional Japanese Herbal Medicine <em>Daikenchuto</em> Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5967
OP 5974
VO 37
IS 11
A1 MITSURU ISHIZUKA
A1 NORISUKE SHIBUYA
A1 HITOSHI NAGATA
A1 KAZUTOSHI TAKAGI
A1 YOSHIMI IWASAKI
A1 HIROYUKI HACHIYA
A1 TAKU AOKI
A1 KEIICHI KUBOTA
YR 2017
UL http://ar.iiarjournals.org/content/37/11/5967.abstract
AB Aim: Although it has been widely demonstrated that administration of Daikenchuto (DKT), a traditional Japanese herbal medicine, improves gastrointestinal (GI) motility in patients undergoing abdominal surgery, few studies have investigated the efficacy of perioperative DKT administration for relief of postoperative ileus (PI) in patients undergoing surgery for GI cancer. Therefore, the aim of this study was to investigate whether perioperative administration of DKT relieves PI in patients with GI cancer. Patients and Methods: We performed a comprehensive electronic search of the literature (Cochrane Library, PubMed, the Web of Science and ICHUSHI) up to December 2016 to identify studies that had shown the efficacy of perioperative DKT administration for relief of PI in patients with GI cancer. To integrate the individual effect of DKT, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI), and heterogeneity was analyzed using I2 statistics. Results: Seven studies involving a total of 1,134 patients who had undergone GI cancer surgery were included in this meta-analysis. Among 588 patients who received DKT perioperatively, 67 (11.4%) had PI, whereas among 546 patients who did not receive DKT perioperatively, 87 (15.9%) had PI. Perioperative administration of DKT significantly reduced the occurrence of PI (RR=0.58, 95% CI=0.35-0.97, p=0.04, I2=48%) in comparison to patients who did not receive DKT or received placebo. Conclusion: The result of this meta-analysis suggests that perioperative administration of DKT relieves PI in patients undergoing surgery for GI cancer.