PT - JOURNAL ARTICLE AU - MITSURU ISHIZUKA AU - NORISUKE SHIBUYA AU - HITOSHI NAGATA AU - KAZUTOSHI TAKAGI AU - YOSHIMI IWASAKI AU - HIROYUKI HACHIYA AU - TAKU AOKI AU - KEIICHI KUBOTA TI - Perioperative Administration of Traditional Japanese Herbal Medicine <em>Daikenchuto</em> Relieves Postoperative Ileus in Patients Undergoing Surgery for Gastrointestinal Cancer: A Systematic Review and Meta-analysis DP - 2017 Nov 01 TA - Anticancer Research PG - 5967--5974 VI - 37 IP - 11 4099 - http://ar.iiarjournals.org/content/37/11/5967.short 4100 - http://ar.iiarjournals.org/content/37/11/5967.full SO - Anticancer Res2017 Nov 01; 37 AB - Aim: Although it has been widely demonstrated that administration of Daikenchuto (DKT), a traditional Japanese herbal medicine, improves gastrointestinal (GI) motility in patients undergoing abdominal surgery, few studies have investigated the efficacy of perioperative DKT administration for relief of postoperative ileus (PI) in patients undergoing surgery for GI cancer. Therefore, the aim of this study was to investigate whether perioperative administration of DKT relieves PI in patients with GI cancer. Patients and Methods: We performed a comprehensive electronic search of the literature (Cochrane Library, PubMed, the Web of Science and ICHUSHI) up to December 2016 to identify studies that had shown the efficacy of perioperative DKT administration for relief of PI in patients with GI cancer. To integrate the individual effect of DKT, a meta-analysis was performed using random-effects models to calculate the risk ratio (RR) and 95% confidence interval (CI), and heterogeneity was analyzed using I2 statistics. Results: Seven studies involving a total of 1,134 patients who had undergone GI cancer surgery were included in this meta-analysis. Among 588 patients who received DKT perioperatively, 67 (11.4%) had PI, whereas among 546 patients who did not receive DKT perioperatively, 87 (15.9%) had PI. Perioperative administration of DKT significantly reduced the occurrence of PI (RR=0.58, 95% CI=0.35-0.97, p=0.04, I2=48%) in comparison to patients who did not receive DKT or received placebo. Conclusion: The result of this meta-analysis suggests that perioperative administration of DKT relieves PI in patients undergoing surgery for GI cancer.