TY - JOUR T1 - Differences in Urinary Renal Failure Biomarkers in Cancer Patients Initially Treated with Cisplatin JF - Anticancer Research JO - Anticancer Res SP - 5235 LP - 5239 VL - 37 IS - 9 AU - AKIMITSU MAEDA AU - HITOSHI ANDO AU - TAKASHI URA AU - KEI MURO AU - MASAHIRO AOKI AU - KEN SAITO AU - EISAKU KONDO AU - SHINJI TAKAHASHI AU - YUKO ITO AU - YASUNARI MIZUNO AU - AKIO FUJIMURA Y1 - 2017/09/01 UR - http://ar.iiarjournals.org/content/37/9/5235.abstract N2 - Background/Aim: We investigated whether measuring the excretion of each acute kidney injury (AKI) biomarker after cisplatin (CDDP) administration is useful for predicting AKI and evaluated the most appropriate AKI marker in patients treated with CDDP. Patients and Methods: We measured NAG, Kim-1, and NGAL in urinary samples of 40 cancer patients treated with chemotherapy on day 1 (before chemotherapy), day 2, and day 5 after treatment; serum creatinine (sCr) was compared on days 7 and 28 after CDDP administration vs. baseline. Results: NAG, Kim-1, and NGAL excretion (creatinine corrected) were not significantly elevated 5 days after receiving chemotherapy in the non-CDDP chemotherapy group. Conversely, all markers were significantly higher 5 days after receiving chemotherapy in the CDDP group when compared to baseline. Conclusion: Urinary NAG, Kim-1, and NGAL can detect renal injury more sensitively than sCr. ER -