TY - JOUR T1 - The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to <em>KRAS</em> Gene Status JF - Anticancer Research JO - Anticancer Res SP - 4953 LP - 4960 VL - 37 IS - 9 AU - JULIA K. BAR AU - ANNA LIS-NAWARA AU - PIOTR GRELEWSKI AU - LESZEK NOGA AU - ZYGMUNT GRZEBIENIAK AU - MICHAŁ JELEŃ Y1 - 2017/09/01 UR - http://ar.iiarjournals.org/content/37/9/4953.abstract N2 - Aim: The aim of this study was to investigate heat shock protein 90 (HSP90) and topoisomerase I (Topo I) expression and the association between both proteins and clinicopathological parameters of colorectal cancer (CRC), in order to describe their role in tumor biology regarding to Kirsten Ras (KRAS) – positive/negative cases. Materials and Methods: Expression of HSP90 and Topo I, and KRAS gene mutations were estimated in primary CRCs. Results: HSP90/Topo I immunophenotype correlated with gender, Duke staging, tumor grade and lymph node metastasis (p&lt;0.01). Positive correlation was found between KRAS mutation and HSP90 expression (p=0.02). HSP90, Topo I expression, and co-expression of HSP90/Topo I correlated with unfavorable parameters of CRCs in respect to KRAS gene status (p&lt;0.001). Conclusion: Our results revealed that cooperation between HSP90 and Topo I expression exists in CRCs, independently of KRAS gene status, suggesting that co-expression of both proteins might be considered as a double target on individual tumor cells. ER -