RT Journal Article SR Electronic T1 The Association Between HSP90/topoisomerase I Immunophenotype and the Clinical Features of Colorectal Cancers in Respect to KRAS Gene Status JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4953 OP 4960 VO 37 IS 9 A1 JULIA K. BAR A1 ANNA LIS-NAWARA A1 PIOTR GRELEWSKI A1 LESZEK NOGA A1 ZYGMUNT GRZEBIENIAK A1 MICHAŁ JELEŃ YR 2017 UL http://ar.iiarjournals.org/content/37/9/4953.abstract AB Aim: The aim of this study was to investigate heat shock protein 90 (HSP90) and topoisomerase I (Topo I) expression and the association between both proteins and clinicopathological parameters of colorectal cancer (CRC), in order to describe their role in tumor biology regarding to Kirsten Ras (KRAS) – positive/negative cases. Materials and Methods: Expression of HSP90 and Topo I, and KRAS gene mutations were estimated in primary CRCs. Results: HSP90/Topo I immunophenotype correlated with gender, Duke staging, tumor grade and lymph node metastasis (p<0.01). Positive correlation was found between KRAS mutation and HSP90 expression (p=0.02). HSP90, Topo I expression, and co-expression of HSP90/Topo I correlated with unfavorable parameters of CRCs in respect to KRAS gene status (p<0.001). Conclusion: Our results revealed that cooperation between HSP90 and Topo I expression exists in CRCs, independently of KRAS gene status, suggesting that co-expression of both proteins might be considered as a double target on individual tumor cells.