RT Journal Article SR Electronic T1 The Diagnostic Significance of Serum Alcohol Dehydrogenase Isoenzymes and Aldehyde Dehydrogenase Activity in Prostate Cancer Patients JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 4961 OP 4965 VO 37 IS 9 A1 KAROLINA ORYWAL A1 WOJCIECH JELSKI A1 TADEUSZ WEREL A1 MACIEJ SZMITKOWSKI YR 2017 UL http://ar.iiarjournals.org/content/37/9/4961.abstract AB Background/Aim: The aim of this study was to investigate a potential role of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) as tumor markers for prostate cancer (PCa). Materials and Methods: Serum samples were obtained from 52 patients with PCa, 34 patients with benign prostatic hyperplasia (BPH) and 60 healthy subjects. Class III and IV of ADH and total ADH activity were measured by the photometric method. For measurement of class I and II ADH and ALDH activity, the fluorometric method was employed. Results: Significantly higher total activity of ADH, ADH III and ADH IV were found in the sera of both, PCa and BPH patients compared with healthy individuals. The diagnostic sensitivity for ADH III activity was 94.2%, specificity 100%, PPV (positive predictive value) and NPV (negative predictive value) were 100% and 95.2% respectively. Area under receiver-operating characteristics (ROC) curve for ADH III activity was 0.993. Conclusion: The results suggest a potential role of ADH III activity as a parameter included in the panel of markers for PCa.