PT - JOURNAL ARTICLE AU - FUSANORI YOTSUMOTO AU - SATOSHI FUKAGAWA AU - KOHEI MIYATA AU - SUNG OUK NAM AU - TAKAHIRO KATSUDA AU - DAISUKE MIYAHARA AU - TAKASHI ODAWARA AU - SADAO MANABE AU - TOYOKAZU ISHIKAWA AU - SHIN'ICHIRO YASUNAGA AU - SHINGO MIYAMOTO TI - HB-EGF Is a Promising Therapeutic Target for Lung Cancer with Secondary Mutation of <em>EGFR<sup>T790M</sup></em> DP - 2017 Jul 01 TA - Anticancer Research PG - 3825--3831 VI - 37 IP - 7 4099 - http://ar.iiarjournals.org/content/37/7/3825.short 4100 - http://ar.iiarjournals.org/content/37/7/3825.full SO - Anticancer Res2017 Jul 01; 37 AB - Advanced lung cancer is one of the most lethal malignancies. Many anticancer agents have been developed for lung cancer with epidermal growth factor receptor (EGFR) mutations, but its prognosis remains extremely poor. The development of molecularly-targeted therapies is required for patients with lung cancer with secondary mutation of the EGFR gene. In this study, in order to assess the validity of heparin-binding EGF-like growth factor (HB-EGF) as a therapeutic target for lung cancer with EGFR mutation, we examined the antitumor effects of a specific inhibitor (cross-reacting material 197; CRM197) on lung cancer cells with EGFR mutation. HB-EGF was the most predominantly expressed EGFR ligand in lung cancer cells with EGFR mutation. CRM197 induced significant cell apoptosis and marked suppression of tumorigenicity in lung cancer cells with single or double mutation of EGFR. These results suggest that HB-EGF is a rational target for the treatment of lung cancer with EGFR mutation.