RT Journal Article
SR Electronic
T1 Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3763
OP 3769
VO 37
IS 7
A1 NOBORU HARADA
A1 TOMOHARU YOSHIZUMI
A1 YO-ICHI YAMASHITA
A1 YUJI SOEJIMA
A1 TORU IKEGAMI
A1 NORIFUMI HARIMOTO
A1 SHINJI ITOH
A1 YOSHIHIKO MAEHARA
YR 2017
UL http://ar.iiarjournals.org/content/37/7/3763.abstract
AB Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy.