PT - JOURNAL ARTICLE AU - NOBORU HARADA AU - TOMOHARU YOSHIZUMI AU - YO-ICHI YAMASHITA AU - YUJI SOEJIMA AU - TORU IKEGAMI AU - NORIFUMI HARIMOTO AU - SHINJI ITOH AU - YOSHIHIKO MAEHARA TI - Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection DP - 2017 Jul 01 TA - Anticancer Research PG - 3763--3769 VI - 37 IP - 7 4099 - http://ar.iiarjournals.org/content/37/7/3763.short 4100 - http://ar.iiarjournals.org/content/37/7/3763.full SO - Anticancer Res2017 Jul 01; 37 AB - Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy.