TY - JOUR T1 - Impact and Prediction of Lymph Node Involvement in Patients with Intrahepatic Cholangiocarcinoma After Curative Resection JF - Anticancer Research JO - Anticancer Res SP - 3763 LP - 3769 VL - 37 IS - 7 AU - NOBORU HARADA AU - TOMOHARU YOSHIZUMI AU - YO-ICHI YAMASHITA AU - YUJI SOEJIMA AU - TORU IKEGAMI AU - NORIFUMI HARIMOTO AU - SHINJI ITOH AU - YOSHIHIKO MAEHARA Y1 - 2017/07/01 UR - http://ar.iiarjournals.org/content/37/7/3763.abstract N2 - Background: The aim of this study was to identify the preoperative predictors of prognosis in patients with intrahepatic cholangiocarcinoma (ICC) undergoing resection. Patients and Methods: We enrolled 90 patients with ICC who underwent surgical resection, including 59 in whom surgery was considered curative, and measured the overall survival (OS), recurrence-free survival (RFS), and other outcomes and potential prognostic factors. Results: Multivariate Cox proportional hazards analysis showed that tumor in the resection margins (R>0) independently predicted long-term OS in the whole cohort. In the curatively-resected group (R0), lymph node involvement was the only independent predictor of long-term OS. Multiple tumors, perihilar tumor location and serum carcinoembryonic antigen (CEA) concentration >2.2 ng/ml were independent predictors of lymph node involvement before curative resection. Conclusion: Patients with ICC with multiple tumors, perihilar tumors and serum CEA concentration >2.2 ng/ml in association with lymph node involvement may need additional preoperative chemotherapy. ER -