RT Journal Article
SR Electronic
T1 Radiosurgery with a Rotating Gamma System: A Very Effective Treatment for Symptomatic Cerebral Cavernomas
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3729
OP 3733
VO 37
IS 7
A1 PHAM CAM PHUONG
A1 NGUYEN DUC LUAN
A1 VO THI HUYEN TRANG
A1 STEVEN E. SCHILD
A1 DIRK RADES
A1 MAI TRONG KHOA
YR 2017
UL http://ar.iiarjournals.org/content/37/7/3729.abstract
AB Aim: To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomas. Patients and Methods: Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size. Results: Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patients. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomes. Conclusion: RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomas.