RT Journal Article
SR Electronic
T1 Frequency of Myeloid-derived Suppressor Cells in the Peripheral Blood Reflects the Status of Tumor Recurrence
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3863
OP 3869
VO 37
IS 7
A1 TANAKA, TOMOKO
A1 FUJITA, MITSUGU
A1 HASEGAWA, HIROSHI
A1 ARIMOTO, AKIRA
A1 NISHI, MASAYASU
A1 FUKUOKA, EIJI
A1 SUGITA, YUTAKA
A1 MATSUDA, TAKERU
A1 SUMI, YASUO
A1 SUZUKI, SATOSHI
A1 KAKEJI, YOSHIHIRO
A1 YAMASHITA, KIMIHIRO
YR 2017
UL http://ar.iiarjournals.org/content/37/7/3863.abstract
AB Background: Malignant tumors inhibit antitumor immune responses, which are driven by T-regulatory cells or myeloid-derived suppressor cells (MDSCs). Since MDSCs are involved in invasion, migration, and metastasis of tumor cells, we hypothesized that MDSCs are also involved in tumor recurrence after surgical resection. Materials and Methods: C57BL/6 mice were subcutaneously inoculated with B16F10 melanoma cells in the right flank. In some experiments, established tumors were surgically resected. Peripheral blood was drawn over time, and immune cells and cytokines were evaluated using flow cytometry. Results: MDSCs and relevant pro-inflammatory cytokines increased in the peripheral blood of tumor-bearing mice. Moreover, the frequency of MDSCs rapidly increased in mice with tumor recurrence. Conclusion: The frequency of MDSCs in the peripheral blood of tumor-bearing mice reflects the status of tumor progression as well as tumor recurrence. Continuous monitoring of MDSCs in the peripheral blood might be a useful indicator of tumor recurrence.