TY - JOUR T1 - Primary Non-Hodgkin's Lymphoma of the Gallbladder: A Population-based Analysis JF - Anticancer Research JO - Anticancer Res SP - 2581 LP - 2586 VL - 37 IS - 5 AU - ADIL AYUB AU - SADIQ REHMANI AU - ADNAN M. AL-AYOUBI AU - ERIK LEWIS AU - NORBERTO SANTANA-RODRÍGUEZ AU - WISSAM RAAD AU - FAIZ BHORA AU - GRACE KIM Y1 - 2017/05/01 UR - http://ar.iiarjournals.org/content/37/5/2581.abstract N2 - Background/Aim: Primary Non-Hodgkin's lymphoma of the gallbladder (PNHL-GB) is extremely rare and data on clinical characteristics, optimal management and outcomes of these patients are limited to anecdotal reporting. We, therefore, sought to examine these patients using a population-based database. Materials and Methods: Surveillance, epidemiology, and end results (SEER) database was queried between 1973 and 2013. Results: One hundred and six cases with PNHL-GB were identified (mean age=70.5 ±15 years, whites 92%, male: female 1.03:1). The majority of patients had loco-regional disease (61%) and DLBCL histology (33%). Ninenty cases (85%) had undergone surgical resection, 6 (5.6%) received radiotherapy. Median overall survival (OS) of the entire cohort was 41 months with a 5-year survival rate of 40%. Patients receiving adjuvant RT had superior OS compared to surgery alone (140 ±27 vs. 86 ±16 months, respectively) and patients with DLBCL demonstrated lower survival compared to other histologies (13 vs. 53 months, respectively, p=0.034). Conclusion: Our study presents the largest dataset of PNHL-GB describing clinical features and outcomes of these patients in addition to summarizing the literature. ER -