PT  - JOURNAL ARTICLE
AU  - DAVID KALFERT
AU  - MARIE LUDVIKOVA
AU  - ONDREJ TOPOLCAN
AU  - PETR CELAKOVSKY
AU  - RADEK KUCERA
AU  - JINDRA WINDRICHOVA
AU  - JAROSLAV LUDVIK
AU  - KATERINA SKALOVA
AU  - VLASTIMIL KULDA
AU  - MARTIN PESTA
AU  - JAN PLZAK
TI  - Serum Levels of IGF-1 and IGFBP-3 in Relation to Clinical and Pathobiological Aspects of Head and Neck Squamous Cell Carcinomas
DP  - 2017 Jun 01
TA  - Anticancer Research
PG  - 3281--3286
VI  - 37
IP  - 6
4099  - http://ar.iiarjournals.org/content/37/6/3281.short
4100  - http://ar.iiarjournals.org/content/37/6/3281.full
SO  - Anticancer Res2017 Jun 01; 37
AB  - Background/Aim: Head and neck squamous cell carcinoma (HNSCC) includes tumors of various anatomical sites sharing multifactorial etiopathogenesis and generally dismal response to conventional treatment. The objective of this study was to determine the clinical significance of serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in HNSCC. Patients and Methods: A total of 46 patients, with histologically-confirmed diagnosis of HNSCC (21 oropharyngeal, 21 laryngeal, and 4 hypopharyngeal cancers) were enrolled in this study. IGF-1 and IGFBP-3 serum levels were measured by an immunoradiometric assay using commercial kits. The adjustment of serum levels at 60 years of age was performed. Results: Significant differences were found in IGF-1 serum concentrations between patients with p16 positive and p16 negative HNSCC (p=0.0062), with higher IGF-1 levels in p16 positive tumors, between low-grade and high-grade cancers (p=0.0323) only in larynx, with elevated IGF-1 concentrations associated with high-grade and between recurrent and non-recurrent HNSCC (p=0.0354), with lower IGF-1 levels in recurrent tumors. Conclusion: The conflicting results of this study may reflect some abnormality of IGF axis regulation in HNSCC, as well as the influence of other etiological factors (e.g. smoking, HPV infection).