RT Journal Article SR Electronic T1 Associating Liver Partition and Portal Vein Occlusion, Including Venous Congestion, Induction in Rats JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 2919 OP 2925 VO 37 IS 6 A1 DAISUKE KAWAGUCHI A1 YUKIHIKO HIROSHIMA A1 YUTARO KIKUCHI A1 KENICHI MATSUO A1 KUNIYA TANAKA YR 2017 UL http://ar.iiarjournals.org/content/37/6/2919.abstract AB Background/Aim: Associating liver partition with portal vein occlusion for staged hepatectomy (ALPPS) is a recently developed strategy for inducing rapid hypertrophy of the future liver remnant (FLR). To explore possible mechanisms, we designed the first model of ALPPS with venous congestion (ALPPS+C) in rats. Materials and Methods: Rats were assigned randomly to 3 experimental groups: ALPPS, ALPPS+C and sham. Hepatic regeneration rate, Ki-67 and histopathology were assessed at 24 h, 48 h, and 7 days postoperatively. Results: Hepatic regeneration rate was much higher for ALPPS+C than for ALPPS at 48 h and 7 days postoperatively (p<0.01). Microscopically, the regenerating liver showed greater hepatocyte density and smaller hepatocyte size in ALPPS+C than in ALPPS (p<0.01 for each). Conclusion: Greater hepatic regeneration in ALPPS+C than in ALPPS confirmed that we established a rat model of ALPPS with benefit from venous congestion. Producing a congested area may contribute importantly to rapid FLR hypertrophy during ALPPS.