TY - JOUR T1 - Epithelial–Mesenchymal Transition in Non Small-cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 1773 LP - 1778 VL - 37 IS - 4 AU - NIKOLAOS TSOUKALAS AU - ELENI ARAVANTINOU-FATOROU AU - MARIA TOLIA AU - CONSTANTINOS GIAGINIS AU - MICHAIL GALANOPOULOS AU - MARIA KIAKOU AU - IOANNIS D. KOSTAKIS AU - EUGENE DANA AU - IOANNIS VAMVAKARIS AU - ATHANASIOS KOROGIANNOS AU - EVANGELOS TSIAMBAS AU - NIKOLAOS SALEMIS AU - GEORGE KYRGIAS AU - ANDREAS KARAMERIS AU - STAMATIOS THEOCHARIS Y1 - 2017/04/01 UR - http://ar.iiarjournals.org/content/37/4/1773.abstract N2 - Background/Aim: Lung cancer is the first cause of cancer related deaths in both males and females. Epithelial–mesenchymal transition (EMT) is a reversible process by which epithelial cells transform to mesenchymal stem cells by losing their cell polarity and cell-to-cell adhesion, gaining migratory and invasive properties. High levels of E-cadherin are expressed in epithelial cells, whereas mesenchymal cells express high levels of N-cadherin, fibronectin and vimentin. The aim of this study was to evaluate the correlation between E-cadherin and vimentin expression and their clinical significance in non-small cell lung cancer (NSCLC). Materials and Methods: The immunohistochemical expression of E-cadherin, vimentin and Ki-67 was performed on tissue microarrays from NSCLC specimens obtained from 112 newly- diagnosed cases and were studied using classical pathological evaluation. Associations between E-cadherin, vimentin and Ki-67 expression, clinicopathological variables and survival were analyzed. In all cases, a value of p≤0.05 was considered significant. Results: Low E-cadherin expression was significantly correlated with tumor necrosis (p=0.019). Moreover, there was a trend for correlation between high E-cadherin expression and better overall survival (hazard ratio=1.02, and 95% confidence interval=0.45-1.87, p=0.091). There was also a significant negative correlation between vimentin expression and overall survival (hazard ratio=1.13, and 95% confidence interval=0.78-1.65, p=0.026). Additionally, there was a significant negative correlation between vimentin expression and grade I tumors (p=0.031). Finally, a positive correlation trend between vimentin expression and Ki-67 was found (p=0.073). Conclusion: High E-cadherin and low vimentin expression correlate with better prognosis and overall survival. ER -