RT Journal Article
SR Electronic
T1 Immunoregulatory Function of Lymphatic Endothelial Cells in Tumor-draining Lymph Nodes of Human Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 2875
OP 2883
VO 37
IS 6
A1 MAO TOKUMOTO
A1 HIROAKI TANAKA
A1 YUKIE TAUCHI
A1 TATSURO TAMURA
A1 TAKAHIRO TOYOKAWA
A1 KENJIRO KIMURA
A1 KAZUYA MUGURUMA
A1 MASAKAZU YASHIRO
A1 KIYOSHI MAEDA
A1 KOSEI HIRAKAWA
A1 MASAICHI OHIRA
YR 2017
UL http://ar.iiarjournals.org/content/37/6/2875.abstract
AB Background/Aim: Lymph node metastasis is the most important prognostic factor for patients with gastric cancer. Increasing evidence suggests that lymphatic endothelial cells (LECs) regulate immune responses. The aim of this study was to examine the effect of LECs on the activation of CD4+ T cells. Materials and Methods: We examined the impact of cancer cells on the phenotype and production of cytokines of LECs derived from tumor-draining lymph nodes. Results: We showed that LECs inhibited CD4+ T cell production of cytokines, such as IL-2, IL-10, and INF-γ. The mRNA expression of programmed death-ligand 1 (PD-L1) and indoleamine 2, 3-dioxygenase (IDO) by LECs were significantly up-regulated when the LECs and CD4+ T cells were co-cultured with cells of the gastric cancer cell line, OCUM12. Conclusion: Intranodal LECs may be a key player in the induction of immune tolerance against cancer and in facilitating metastasis through lymphatic vessels in gastric cancer.