RT Journal Article
SR Electronic
T1 Characterization of Leiomyomatoid Angiomatous Neuroendocrine Tumour (LANT)-like Tumour in the Myometrium with Histopathological Examination
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1765
OP 1772
VO 37
IS 4
A1 TAKUMA HAYASHI
A1 TOMOYUKI ICHIMURA
A1 MARI KASAI
A1 KENJI SANO
A1 DORIT ZHARHARY
A1 TANRI SHIOZAWA
A1 NOBUO YAEGASHI
A1 IKUO KONISHI
YR 2017
UL http://ar.iiarjournals.org/content/37/4/1765.abstract
AB Leiomyomatoid angiomatous neuroendocrine tumour (LANT) is possibly a new disease entity that was reported as a dimorphic neurosecretory tumour with a leiomyomatous vascular component; it was found in the pituitary. We describe uterine LANT-like malignant tumour in a 45-year-old woman with uterine mesenchymal tumour, diagnosed clinically as uterine leiomyoma. She underwent laparoscopic myomectomy. The tumour consisted of hyalinized vasculature, containing factor VIII-positive endothelium and α-smooth muscle actin-positive vascular smooth muscle cells, and stromal cells, expressing neuroadhesion molecules. Both vascular and stromal components diffusely expressed chromogranin A. Histopathological examinations of uterine LANT-like malignant tumour revealed the common characteristic abnormalities of malignant uterine mesenchymal tumours, i.e. leiomyosarcomas. From our research, defective expression of calponin H1 and proteasome β9 (PSMB9)/β1i is observed in uterine LANT-like malignant tumour similarly to immunopathological findings of uterine leiomyosarcoma. These findings meet the definition of uterine LANT-like malignant tumour, and the research findings of our clinical case suggest that LANT is a special type of neuroendocrine neoplasm and is not organ specific.