RT Journal Article
SR Electronic
T1 Clinical Features and Outcome of Surgical Patients with Non-B Non-C Hepatocellular Carcinoma
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 3207
OP 3213
VO 37
IS 6
A1 SHIGEKI WAKIYAMA
A1 MICHINORI MATSUMOTO
A1 KOICHIRO HARUKI
A1 TAKESHI GOCHO
A1 TARO SAKAMOTO
A1 HIROAKI SHIBA
A1 YASURO FUTAGAWA
A1 YUICHI ISHIDA
A1 KATSUHIKO YANAGA
YR 2017
UL http://ar.iiarjournals.org/content/37/6/3207.abstract
AB Aim: To investigate the clinical characteristics and prognosis of surgical patients with non-B non-C hepatocellular carcinoma (NBNC-HCC) compared to those of hepatitis B virus (HBV)- and hepatitis C virus (HCV)-HCC. Patients and Methods: Clinical data and outcomes were compared among the three groups. Prognostic factors of patients with NBNC-HCC were investigated. Results: Compared to HBV-HCC, patients with NBNC-HCC had higher chance of hypertension (HTN) (p<0.01), diabetes mellitus (DM) and body mass index (BMI) >25 kg/m2. Compared to HCV-HCC, patients with NBNC-HCC had higher incidence of DM and higher BMI >25 kg/m2 (p<0.01). There were no significant differences in overall survival (OS) rate among the three groups. In patients with NBNC-HCC, albumin (Alb; p<0.05) was an independent prognostic factor of OS, while Alb and α-fetoprotein (AFP) were independent prognostic factors of disease-free survival (DFS; p<0.01 each). Conclusion: Surgical patients with NBNC-HCC often have concomitant DM, HTN and high BMI, for whom factors related to prognosis were Alb and AFP.