PT - JOURNAL ARTICLE AU - JEONG HO MOON AU - YOSHIYUKI FUJIWARA AU - MOTOHIRO HIRAO AU - HIROSHI IMAMURA AU - YUTAKA KIMURA AU - KAZUMASA FUJITANI AU - JUNYA FUJITA AU - SHIGEYUKI TAMURA AU - SHUJI TAKIGUCHI AU - MASAHIKO YANO AU - MASAKI MORI AU - YUICHIRO DOKI TI - Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines <em>Versus</em> Surgery-alone for Gastric Cancer DP - 2017 Jun 01 TA - Anticancer Research PG - 3061--3067 VI - 37 IP - 6 4099 - http://ar.iiarjournals.org/content/37/6/3061.short 4100 - http://ar.iiarjournals.org/content/37/6/3061.full SO - Anticancer Res2017 Jun 01; 37 AB - Aim: This prospective randomized study compared the survival of patients with stage IB-IIIA gastric cancer treated with surgery alone or surgery followed by adjuvant chemotherapy. Patients and Methods: Patients with pathological stage IB-IIIA disease were randomly assigned to the following groups: surgery alone (n=116), or surgery followed by adjuvant chemotherapy with 5-fluorouracil, doxifluridine, or uracil-tegafur for 12 months (n=113). Results: The overall survival rate was 86.1% in the adjuvant group and 78.5% in the surgery-alone group. The overall survival rate did not significantly differ between the adjuvant-chemotherapy and surgery-only groups (p=0.163). In the subgroup analyses, patients with stage II disease and those receiving uracil-tegafur treatment in the adjuvant group showed significantly better prognosis than those in the surgery-alone group (p=0.036 and 0.005, respectively). Conclusion: This study did not find a significant survival benefit to be associated with adjuvant chemotherapy with fluoropyrimidines in patients with stage IB-IIIA gastric cancer. However, it may be effective for patients with stage II disease. Additionally, uracil-tegafur is a promising agent for adjuvant chemotherapy of gastric cancer if S-1 is not available because of its toxicity.