RT Journal Article
SR Electronic
T1 Low Variability and Stable Frequency of Common Haplotypes of the <em>TP53</em> Gene Region in Colorectal Cancer Patients in a Slovak Population
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1901
OP 1907
VO 37
IS 4
A1 ŠKEREŇOVÁ, MÁRIA
A1 HALAŠOVÁ, ERIKA
A1 MATÁKOVÁ, TATIANA
A1 JESENSKÁ, ĽUBICA
A1 JUREČEKOVÁ, JANA
A1 ŠARLINOVÁ, MIROSLAVA
A1 ČIERNY, DANIEL
A1 DOBROTA, DUŠAN
YR 2017
UL http://ar.iiarjournals.org/content/37/4/1901.abstract
AB Aim: To test the association between common TP53 haplotypes and colorectal cancer (CRC) development. Patients and Methods: A total of 277 CRC patients and 167 healthy volunteers were included in the study. Common TP53 haplotypes were estimated from eight single-nucleotide polymorphisms (SNPs) (rs1614984, rs77697176, rs12947788, rs1800372, rs2909430, rs1042522, rs17878362 and rs11652704). Stepwise haplotype trend regression showed the haplotype-regressor cccgaRDa as a possible predictive marker. Results: The rare haplotype cccgaRDa was identified in 10 CRC cases and 3 controls. Although it is approximately twice as common in CRC (odds ratio (OR)=2.068; 95% confidence interval (CI)=0.471-9.069), the cccgaRDa haplotype frequency is low in the studied groups. Results of our study suggest that the common TP53 variability is relatively low (only 3 haplotypes occurred above 10%). Conclusion: The haplotype background of TP53 gene is relative stable and despite low haplotype-regressor cccgaRDa frequency it shows to be a possible predictive parameter for CRC development.