PT  - JOURNAL ARTICLE
AU  - ŠKEREŇOVÁ, MÁRIA
AU  - HALAŠOVÁ, ERIKA
AU  - MATÁKOVÁ, TATIANA
AU  - JESENSKÁ, ĽUBICA
AU  - JUREČEKOVÁ, JANA
AU  - ŠARLINOVÁ, MIROSLAVA
AU  - ČIERNY, DANIEL
AU  - DOBROTA, DUŠAN
TI  - Low Variability and Stable Frequency of Common Haplotypes of the <em>TP53</em> Gene Region in Colorectal Cancer Patients in a Slovak Population
DP  - 2017 Apr 01
TA  - Anticancer Research
PG  - 1901--1907
VI  - 37
IP  - 4
4099  - http://ar.iiarjournals.org/content/37/4/1901.short
4100  - http://ar.iiarjournals.org/content/37/4/1901.full
SO  - Anticancer Res2017 Apr 01; 37
AB  - Aim: To test the association between common TP53 haplotypes and colorectal cancer (CRC) development. Patients and Methods: A total of 277 CRC patients and 167 healthy volunteers were included in the study. Common TP53 haplotypes were estimated from eight single-nucleotide polymorphisms (SNPs) (rs1614984, rs77697176, rs12947788, rs1800372, rs2909430, rs1042522, rs17878362 and rs11652704). Stepwise haplotype trend regression showed the haplotype-regressor cccgaRDa as a possible predictive marker. Results: The rare haplotype cccgaRDa was identified in 10 CRC cases and 3 controls. Although it is approximately twice as common in CRC (odds ratio (OR)=2.068; 95% confidence interval (CI)=0.471-9.069), the cccgaRDa haplotype frequency is low in the studied groups. Results of our study suggest that the common TP53 variability is relatively low (only 3 haplotypes occurred above 10%). Conclusion: The haplotype background of TP53 gene is relative stable and despite low haplotype-regressor cccgaRDa frequency it shows to be a possible predictive parameter for CRC development.