RT Journal Article
SR Electronic
T1 Telomere Length in Leukocyte DNA in Gastric Cancer Patients and its Association with Clinicopathological Features and Prognosis
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1997
OP 2001
VO 37
IS 4
A1 TAHARA, TOMOMITSU
A1 TAHARA, SAYUMI
A1 HORIGUCHI, NORIYUKI
A1 KAWAMURA, TOMOHIKO
A1 OKUBO, MASAAKI
A1 ISHIZUKA, TAKAMITSU
A1 YAMADA, HYUGA
A1 YOSHIDA, DAI
A1 OHMORI, TAKAFUMI
A1 MAEDA, KOHEI
A1 KOMURA, NARUOMI
A1 IKUNO, HIROKAZU
A1 JODAI, YASUTAKA
A1 KAMANO, TOSHIAKI
A1 NAGASAKA, MITSUO
A1 NAKAGAWA, YOSHIHITO
A1 TUSKAMOTO, TETSUYA
A1 URANO, MAKOTO
A1 SHIBATA, TOMOYUKI
A1 KURODA, MAKOTO
A1 OHMIYA, NAOKI
YR 2017
UL http://ar.iiarjournals.org/content/37/4/1997.abstract
AB Background/Aim: Telomere shortening in leukocytes has been thought to be associated with reduced immune response capacity and increased chromosome instability. Several studies indicate that telomere length in the peripheral blood leukocyte DNA can predict clinical outcome of several cancers. We evaluated the potential association between telomere shortening in the leukocyte DNA and clinicopathological features and prognosis of gastric cancer (GC) in Japanese patients. Materials and Methods: Telomere length in leukocyte DNA was measured using quantitative real-time polymerase chain reaction (PCR) in 207 GC patients. The association between telomere length and clinicopathological features and prognosis was evaluated. Results: These short-telomere group was significantly associated with advanced stage (p=0.015), worse overall survival (OS) and progression-free survival (PFS) (p=0.046 and 0.026, respectively). The same group was also weakly associated with overall and peritoneal recurrences (p=0.052 and 0.059, respectively). Conclusion: Telomere shortening in leukocyte DNA is associated with advanced stage and poor prognosis of GC, which may reflect their reduced immune response capacity or increased chromosome instability.