RT Journal Article
SR Electronic
T1 Liposomes Incorporating Transferrin and Stearic Acid-modified Octa-arginine for siRNA Delivery
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1759
OP 1764
VO 37
IS 4
A1 DONGSHENG YANG
A1 XUEWEI YANG
A1 ROBERT J. LEE
A1 SONGCAI LIU
A1 JING XIE
YR 2017
UL http://ar.iiarjournals.org/content/37/4/1759.abstract
AB Liposomes incorporating stearic acid-modified octa-arginine (StA-R8) and conjugated to transferrin (Tf) were synthesized and evaluated for delivery of small interfering RNA (siRNA) against survivin. Characteristics, cytotoxicity, cellular uptake and biological activity of liposomes complexed to survivin siRNA were investigated. Tf-conjugated liposomes were shown to have reduced cytotoxicity and improved delivery efficiency for siRNA into cancer cells compared to non-conjugated StA-R8 liposomes. These data suggest that Tf-conjugated StA-R8 liposomes are promising vehicles for siRNA delivery in cancer therapy.