PT - JOURNAL ARTICLE AU - DONGSHENG YANG AU - XUEWEI YANG AU - ROBERT J. LEE AU - SONGCAI LIU AU - JING XIE TI - Liposomes Incorporating Transferrin and Stearic Acid-modified Octa-arginine for siRNA Delivery DP - 2017 Apr 01 TA - Anticancer Research PG - 1759--1764 VI - 37 IP - 4 4099 - http://ar.iiarjournals.org/content/37/4/1759.short 4100 - http://ar.iiarjournals.org/content/37/4/1759.full SO - Anticancer Res2017 Apr 01; 37 AB - Liposomes incorporating stearic acid-modified octa-arginine (StA-R8) and conjugated to transferrin (Tf) were synthesized and evaluated for delivery of small interfering RNA (siRNA) against survivin. Characteristics, cytotoxicity, cellular uptake and biological activity of liposomes complexed to survivin siRNA were investigated. Tf-conjugated liposomes were shown to have reduced cytotoxicity and improved delivery efficiency for siRNA into cancer cells compared to non-conjugated StA-R8 liposomes. These data suggest that Tf-conjugated StA-R8 liposomes are promising vehicles for siRNA delivery in cancer therapy.