TY - JOUR T1 - MDS/AML del(11)(q14) Share Common Morphological Features Despite Different Chromosomal Breakpoints JF - Anticancer Research JO - Anticancer Res SP - 645 LP - 649 VL - 37 IS - 2 AU - IRENE DAMBRUOSO AU - ROSANGELA INVERNIZZI AU - MARINA BONI AU - RITA ZAPPATORE AU - ILARIA GIARDINI AU - MARIA PAOLA CAVIGLIANO AU - BARBARA ROCCA AU - CELESTE CALVELLO AU - RAFFAELLA BASTIA AU - MARILENA CARESANA AU - FRANCESCA PASI AU - ROSANNA NANO AU - PAOLO BERNASCONI Y1 - 2017/02/01 UR - http://ar.iiarjournals.org/content/37/2/645.abstract N2 - In myelodysplatic syndromes and acute myeloid leukemia (MDS/AML) deletion of the 11q14 region is a rare chromosomal defect (incidence: 0.6-1.0%), included within the intermediate risk criteria by the International Prognostic Scoring System. No fluorescence in situ hybridization (FISH) study has yet been performed to identify a common breakpoint region (CBR). In our study through FISH with bacterial artificial chromosomes and commercial probes, we analyzed seven patients with MDS/AML harboring 11q14 deletion on conventional cytogenetic analysis. FISH revealed deletions in five patients and amplifications in two. Three patients with deletion carried a CBR, two had a deletion involving a more centromeric breakpoint. These five patients exhibited multilineage dysplasia, blast cells with large round nuclei, loose chromatin, small and abundant nucleoli, and vacuolated cytoplasm with very thin Auer bodies. In conclusion, the morphological features which occur independently of the extent of the deletion are of multilineage dysplasia in MDS and leukemic blasts strongly reactive to peroxidase in AML; despite the variable size of the deleted area, some patients harbor a CBR. ER -