TY - JOUR T1 - Carboplatin plus Weekly Paclitaxel Combined with Bevacizumab as First-line Treatment for Non-small Cell Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 923 LP - 928 VL - 37 IS - 2 AU - MASAHIRO YAMASAKI AU - ISAO MURAKAMI AU - KIKUO NAKANO AU - MIHOKO DOI AU - SOUICHI KITAGUCHI AU - TOMOHIRO KONDO AU - JOJI SAKURAI AU - NOBORU HATTORI AU - KEN-ICHI ARITA Y1 - 2017/02/01 UR - http://ar.iiarjournals.org/content/37/2/923.abstract N2 - Aim: We aimed to evaluate the efficacy and safety of carboplatin plus weekly paclitaxel with bevacizumab in patients with advanced non-squamous non-small cell lung cancer (NSCLC). Patients and Methods: Patients with stage IIIB/IV or postoperative recurrent NSCLC (n=33) were treated with carboplatin (area under the curve of 6) on day 1; paclitaxel (80 mg/m2) on days 1, 8, and 15; and bevacizumab (15 mg/kg) on day 1 repeated every 4 weeks, for four to six cycles; followed by maintenance bevacizumab (15 mg/kg) every 3 weeks. Results: The overall response rate was 76%. The median progression-free survival and overall survival were 8.4 months and 22.2 months, respectively. Grade 3-4 toxicities included neutropenia in 55% of patients, anemia in 18%, febrile neutropenia in 12%, and anorexia in 9%. No treatment-related deaths were observed. Conclusion: Carboplatin plus weekly paclitaxel with bevacizumab was effective and well tolerated by patients with advanced NSCLC. ER -