PT  - JOURNAL ARTICLE
AU  - YAMASAKI, MASAHIRO
AU  - MURAKAMI, ISAO
AU  - NAKANO, KIKUO
AU  - DOI, MIHOKO
AU  - KITAGUCHI, SOUICHI
AU  - KONDO, TOMOHIRO
AU  - SAKURAI, JOJI
AU  - HATTORI, NOBORU
AU  - ARITA, KEN-ICHI
TI  - Carboplatin plus Weekly Paclitaxel Combined with Bevacizumab as First-line Treatment for Non-small Cell Lung Cancer
DP  - 2017 Feb 01
TA  - Anticancer Research
PG  - 923--928
VI  - 37
IP  - 2
4099  - http://ar.iiarjournals.org/content/37/2/923.short
4100  - http://ar.iiarjournals.org/content/37/2/923.full
SO  - Anticancer Res2017 Feb 01; 37
AB  - Aim: We aimed to evaluate the efficacy and safety of carboplatin plus weekly paclitaxel with bevacizumab in patients with advanced non-squamous non-small cell lung cancer (NSCLC). Patients and Methods: Patients with stage IIIB/IV or postoperative recurrent NSCLC (n=33) were treated with carboplatin (area under the curve of 6) on day 1; paclitaxel (80 mg/m2) on days 1, 8, and 15; and bevacizumab (15 mg/kg) on day 1 repeated every 4 weeks, for four to six cycles; followed by maintenance bevacizumab (15 mg/kg) every 3 weeks. Results: The overall response rate was 76%. The median progression-free survival and overall survival were 8.4 months and 22.2 months, respectively. Grade 3-4 toxicities included neutropenia in 55% of patients, anemia in 18%, febrile neutropenia in 12%, and anorexia in 9%. No treatment-related deaths were observed. Conclusion: Carboplatin plus weekly paclitaxel with bevacizumab was effective and well tolerated by patients with advanced NSCLC.