RT Journal Article SR Electronic T1 Relationship Between Ktrans and K1 with Simultaneous Versus Separate MR/PET in Rabbits with VX2 Tumors JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 1139 OP 1148 VO 37 IS 3 A1 KYUNG HEE LEE A1 SEUNG KWAN KANG A1 JIN MO GOO A1 JAE SUNG LEE A1 GI JEONG CHEON A1 SEONGHO SEO A1 EUI JIN HWANG YR 2017 UL http://ar.iiarjournals.org/content/37/3/1139.abstract AB Background/Aim: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic 13N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. Materials and Methods: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function. Results: Assuming a linear relationship, Ktrans and K1 exhibited a moderate positive correlations with both simultaneous (r=0.54-0.57) and separate (r=0.53-0.69) imaging. However, while the Ktrans and K1 from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K1 associated with a unit increase in Ktrans varied depending on Ktrans values. Conclusion: The relationship between Ktrans and K1 may be mis-interpreted with separate MR and PET acquisition.