RT Journal Article
SR Electronic
T1 Relationship Between Ktrans and K1 with Simultaneous Versus Separate MR/PET in Rabbits with VX2 Tumors
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 1139
OP 1148
VO 37
IS 3
A1 KYUNG HEE LEE
A1 SEUNG KWAN KANG
A1 JIN MO GOO
A1 JAE SUNG LEE
A1 GI JEONG CHEON
A1 SEONGHO SEO
A1 EUI JIN HWANG
YR 2017
UL http://ar.iiarjournals.org/content/37/3/1139.abstract
AB Background/Aim: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic 13N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. Materials and Methods: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson's correlation coefficients and linear/non-linear regression function. Results: Assuming a linear relationship, Ktrans and K1 exhibited a moderate positive correlations with both simultaneous (r=0.54-0.57) and separate (r=0.53-0.69) imaging. However, while the Ktrans and K1 from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K1 associated with a unit increase in Ktrans varied depending on Ktrans values. Conclusion: The relationship between Ktrans and K1 may be mis-interpreted with separate MR and PET acquisition.