@article {LEE1139, author = {KYUNG HEE LEE and SEUNG KWAN KANG and JIN MO GOO and JAE SUNG LEE and GI JEONG CHEON and SEONGHO SEO and EUI JIN HWANG}, title = {Relationship Between Ktrans and K1 with Simultaneous Versus Separate MR/PET in Rabbits with VX2 Tumors}, volume = {37}, number = {3}, pages = {1139--1148}, year = {2017}, publisher = {International Institute of Anticancer Research}, abstract = {Background/Aim: To compare the relationship between Ktrans from DCE-MRI and K1 from dynamic 13N-NH3-PET, with simultaneous and separate MR/PET in the VX-2 rabbit carcinoma model. Materials and Methods: MR/PET was performed simultaneously and separately, 14 and 15 days after VX-2 tumor implantation at the paravertebral muscle. The Ktrans and K1 values were estimated using an in-house software program. The relationships between Ktrans and K1 were analyzed using Pearson{\textquoteright}s correlation coefficients and linear/non-linear regression function. Results: Assuming a linear relationship, Ktrans and K1 exhibited a moderate positive correlations with both simultaneous (r=0.54-0.57) and separate (r=0.53-0.69) imaging. However, while the Ktrans and K1 from separate imaging were linearly correlated, those from simultaneous imaging exhibited a non-linear relationship. The amount of change in K1 associated with a unit increase in Ktrans varied depending on Ktrans values. Conclusion: The relationship between Ktrans and K1 may be mis-interpreted with separate MR and PET acquisition.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/37/3/1139}, eprint = {https://ar.iiarjournals.org/content/37/3/1139.full.pdf}, journal = {Anticancer Research} }