RT Journal Article
SR Electronic
T1 Gender Difference in Distribution of Estrogen and Androgen Receptors in Intestinal-type Gastric Cancer
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 197
OP 202
VO 37
IS 1
A1 JUKIC, ZORAN
A1 RADULOVIC, PETRA
A1 STOJKOVIĆ, RANKO
A1 MIJIC, AUGUST
A1 GRAH, JOSIP
A1 KRUSLIN, BOZO
A1 FERENCIC, ZELJKO
A1 FUCIC, ALEKSANDRA
YR 2017
UL http://ar.iiarjournals.org/content/37/1/197.abstract
AB Background: Gender difference in survival of patients with gastric cancer is not well investigated. The aim of this study was to analyze the gender-related distribution of estrogen receptor alpha (ERα) and androgen receptor (AR) in the epithelium and stroma of intestinal-type gastric cancer. Materials and Methods: Immunohistochemical analysis was performed in 60 patients (42% females). Results: In gastric cancer patients, frequency of ERα-positive cells was lower in epithelium than in healthy individuals, but not significantly. In stroma and epithelium, AR-positive cells were absent from samples of women with T1 and T2 stage disease, while in men, their frequency was significantly increased in stroma of those with T3 and T4 stages and was significantly higher compared to women. AR-positive cells in stroma were fibroblasts, myofibroblasts and mast cells. Conclusion: To our knowledge, this study is the first to show gender differences in the distribution and frequency of AR-positive cells in neoplastic stroma of gastric cancer.