RT Journal Article
SR Electronic
T1 Platinum-based Doublet Chemotherapy for Advanced Gastric Cancer with Disseminated Intravascular Coagulation
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 309
OP 313
VO 37
IS 1
A1 KEIJI SUGIYAMA
A1 YUKIYA NARITA
A1 SHIGENORI KADOWAKI
A1 TAKASHI URA
A1 MASAHIRO TAJIKA
A1 KEI MURO
YR 2017
UL http://ar.iiarjournals.org/content/37/1/309.abstract
AB Background: Disseminated intravascular coagulation (DIC) is a rare complication of advanced gastric cancer (AGC). Despite reports of the efficacy of chemotherapy for AGC with DIC, little is known of platinum-based doublet therapy. Patients and Methods: We conducted a single-institute, retrospective chart review of 500 consecutive chemotherapy-naïve patients with advanced gastric adenocarcinoma (recurrent or metastatic) from November 2010 to November 2015. Results: Six patients were diagnosed with AGC with DIC (1.2%); five (1.0%; 3 men, 2 women) received platinum-based doublet chemotherapy. All patients exhibited improved DIC and thrombocytopenia and survived for >100 days (range=114-313) with no therapy-related mortality. Grade ≥3 adverse effects included neutropenia, anemia, hyponatremia, catheter-related infection and diarrhea (maximum: 2 patients each). Conclusion: Fluoropyrimidine plus platinum combination therapy was effective against DIC and yielded acceptable survival outcomes. Combination chemotherapy should be considered as a primary therapy for AGC with DIC.