TY - JOUR T1 - Minimally Invasive Lymphadenectomy in Uterine Cervical Cancer: A Systematic Review JF - Anticancer Research JO - Anticancer Res SP - 335 LP - 342 VL - 37 IS - 1 AU - NATASA RIZOU AU - DEMETRIOS MORIS AU - EMMANOUIL PIKOULIS AU - NIKOLAOS DIMITROKALLIS AU - EUSTRATIA MPAILI AU - EVANGELOS FELEKOURAS AU - ALEXANDROS PAPALAMPROS Y1 - 2017/01/01 UR - http://ar.iiarjournals.org/content/37/1/335.abstract N2 - Background/Aim: The aim of this study was to review the current literature on the role of minimally invasive lymphadenectomy in the treatment of cervical cancer. Materials and Methods: Non-randomized control trials published between January 2007 to May 2016 were identified by searching the Pubmed, EMBASE and Cochrane Library databases. Primary endpoints included operative outcomes (operative time, intraoperative blood loss, number of transfused patients and conversion rates), postoperative outcomes (length of postoperative hospital stay, postoperative morbidity and postoperative in-hospital mortality), and oncological outcomes (number of harvested lymph nodes, tumor recurrence, disease-free rates and overall survival rates). Results: A total of 17 studies with a total of 1,676 patients were included in the review. Compared to the open approach, minimally invasive lymphadenectomy demonstrated a significantly larger number of harvested lymph nodes, longer operative time, lower intraoperative blood loss and shorter postoperative hospital stay. No significant differences were observed between groups treated with an open, laparoscopic or robotic approach for the following criteria: lymph node metastasis, postoperative morbidity, tumor recurrence and postoperative mortality. Conclusion: Although a technically demanding and time-consuming procedure, minimally invasive lymphadenectomy appears to be safe and feasible and may offer an alternative approach in staging and treatment of cervical cancer. Multicentre randomized controlled trials investigating its long-term oncological outcomes and its cost-effectiveness are required to determine the advantages of this procedure over the open approach in cervical cancer. ER -