PT  - JOURNAL ARTICLE
AU  - DAKEUN LEE
AU  - EUN JI YU
AU  - IN-HYE HAM
AU  - HOON HUR
TI  - Clinicopathological Implication of Insulin-like Growth Factor-II mRNA-Binding Protein 3 (IMP3) Expression in Gastric Cancer
DP  - 2017 Jan 01
TA  - Anticancer Research
PG  - 135--142
VI  - 37
IP  - 1
4099  - http://ar.iiarjournals.org/content/37/1/135.short
4100  - http://ar.iiarjournals.org/content/37/1/135.full
SO  - Anticancer Res2017 Jan 01; 37
AB  - Background: The clinicopathological significance of oncofetal mRNA-binding protein, human insulin-like growth factor II mRNA-binding protein 3 (IMP3), in gastric carcinoma (GC) is not fully understood. Materials and Methods: Tissue microarray blocks with specimens from 346 patients with GC were constructed to evaluate the clinicopathological role of IMP3 expression in GC. These results were validated with an online dataset of 876 patients from the Kaplan-Meier Plotter. Sera from 15 controls and 57 patients with GC were collected in order to compare the levels of serum IMP3 between groups. Results: High expression of IMP3 was significantly associated with poor prognosis. Survival curves from the Kaplan-Meier Plotter showed that high IMP3 expression was significantly related to worse disease-free survival and overall survival. Conclusion: Tissue overexpression of IMP3 might be used as a predictor of advanced disease or lymph node metastasis, and is associated with poorer prognosis in GCs.