TY - JOUR T1 - Usefulness of <sup>18</sup>F-α-Methyltyrosine PET for Therapeutic Monitoring of Patients with Advanced Lung Cancer JF - Anticancer Research JO - Anticancer Res SP - 6481 LP - 6490 VL - 36 IS - 12 AU - KYOICHI KAIRA AU - TETSUYA HIGUCHI AU - NORIAKI SUNAGA AU - YUKIKO ARISAKA AU - TAKESHI HISADA AU - HIDEYUKI TOMINAGA AU - NOBORU ORIUCHI AU - TAKAYUKI ASAO AU - YOSHIHITO TSUSHIMA AU - MASANOBU YAMADA Y1 - 2016/12/01 UR - http://ar.iiarjournals.org/content/36/12/6481.abstract N2 - Background/Aim: L-[3-18F]-α-methyl tyrosine (18F-FAMT) positron emission tomography (PET) has a high specificity for detecting malignant lesions. However, the usefulness of therapeutic monitoring of 18F-FAMT PET against advanced human neoplasms remains unclear. Here, we evaluated 18F-FAMT PET clinical significance regarding therapy response and outcome after systemic chemotherapy in patients with advanced lung cancer, compared to 18F-FDG PET. Patients and Methods: All patients with untreated advanced lung cancer received 18F-FAMT PET and 18F-FDG PET before and 4 weeks after one cycle of chemotherapy. Metabolic response (MR) was defined according to the PERCIST guideline. Results: Ninety-five patients were eligible for analysis on both PET scans. The histological type included 87 non-small cell lung cancers and 8 small-cell lung cancers. Post-treatment maximal standardized uptake values (SUVmax) and MR on 18F-FAMT PET were correlated with tumor response. In all patients, post-treatment SUVmax of 18F-FDG and 18F-FAMT PET and MR of 18F-FAMT PET were statistically significant prognostic markers for predicting poor outcome by univariate analysis. Multivariate analysis confirmed that MR on 18F-FAMT PET was a significant independent prognostic factor. Conclusion: MR on 18F-FAMT PET may be a potential parameter to predict the prognosis after first-line chemotherapy in patients with advanced lung cancer. ER -