RT Journal Article
SR Electronic
T1 Multicellular Spheroids as a Model for Hypoxia-induced EMT
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6259
OP 6263
VO 36
IS 12
A1 LEE, CASEY
A1 SIU, AMANDA
A1 RAMOS, DANIEL M.
YR 2016
UL http://ar.iiarjournals.org/content/36/12/6259.abstract
AB Oral cancer is aggressive and invasive. The 5-year survival rate is around 50% and has not improved in over 50 years. One-third of oral cancer patients develop local and/or regional tumor recurrence following treatment. We continue to use our multicellular spheroid (MCS) model to better understand how the extracellular matrix contributes to epithelial to mesenchymal transition and how hypoxia contributes to the progression of oral squamous cell carcinoma (SCC).