PT - JOURNAL ARTICLE AU - LEE, CASEY AU - SIU, AMANDA AU - RAMOS, DANIEL M. TI - Multicellular Spheroids as a Model for Hypoxia-induced EMT DP - 2016 Dec 01 TA - Anticancer Research PG - 6259--6263 VI - 36 IP - 12 4099 - http://ar.iiarjournals.org/content/36/12/6259.short 4100 - http://ar.iiarjournals.org/content/36/12/6259.full SO - Anticancer Res2016 Dec 01; 36 AB - Oral cancer is aggressive and invasive. The 5-year survival rate is around 50% and has not improved in over 50 years. One-third of oral cancer patients develop local and/or regional tumor recurrence following treatment. We continue to use our multicellular spheroid (MCS) model to better understand how the extracellular matrix contributes to epithelial to mesenchymal transition and how hypoxia contributes to the progression of oral squamous cell carcinoma (SCC).