TY - JOUR T1 - Clinical Burden of C-Reactive Protein/Albumin Ratio Before Curative Surgery for Patients with Gastric Cancer JF - Anticancer Research JO - Anticancer Res SP - 6491 LP - 6498 VL - 36 IS - 12 AU - YUJI TOIYAMA AU - TADANOBU SHIMURA AU - HIROMI YASUDA AU - HIROYUKI FUJIKAWA AU - YOSHIKI OKITA AU - MINAKO KOBAYASHI AU - MASAKI OHI AU - SHIGEYUKI YOSHIYAMA AU - JYUNICHIRO HIRO AU - TOSHIMITSU ARAKI AU - YASUHIRO INOUE AU - YASUHIKO MOHRI AU - MASATO KUSUNOKI Y1 - 2016/12/01 UR - http://ar.iiarjournals.org/content/36/12/6491.abstract N2 - To assess the relationship of C-reactive protein/albumin ratio (CAR) to outcomes and surgical site infection (SSI) in gastric cancer (GC) treated with curative intent, we retrospectively assessed 384 patients with GC for CAR, SSIs, disease-free survival (DFS), overall survival (OS) and other factors. We found SSIs in 42 patients (10.9%). Pathological T-stage, TNM classification, body mass index, duration of surgery, blood loss and preoperative CAR were significantly associated with SSIs; in multivariate analyses, CAR [hazard ratio (HR)=2.98, p=0.003] and duration of surgery (HR=2.34, p=0.029) independently predicted SSI. Age, sex, T-and N-stages, tumor size and serum carcinoembryonic antigen (CEA) were associated with high CAR, and high CAR, CEA and CA19-9 combined was associated with shorter OS (p=0.0001) and DFS (p=0.0001). Multivariate analyses also linked high CAR to early recurrence (HR=2.21, p=0.011) and poor prognosis (HR=1.82, p=0.038). We show, for the first time to our knowledge, that a high CAR predicts SSI, early recurrence and poor prognosis in patients with GC treated with curative intent. ER -