RT Journal Article
SR Electronic
T1 Predicting Survival After Irradiation of Metastases from Transitional Carcinoma of the Bladder
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 6663
OP 6665
VO 36
IS 12
A1 MANIG, LISA
A1 KÄSMANN, LUKAS
A1 JANSSEN, STEFAN
A1 RADES, DIRK
YR 2016
UL http://ar.iiarjournals.org/content/36/12/6663.abstract
AB Aim: For patients with metastatic bladder cancer, radiotherapy is a good option to control symptoms and improve outcomes. Potential prognostic factors for survival including the radiation dose were investigated. Patients and Methods: Ten factors were evaluated in 63 patients for association with survival after irradiation namely age, gender, performance status, initial T-category, initial N-category, metastases at initial diagnosis, number of metastases, metastatic sites, radiation dose and time from diagnosis of metastases to irradiation. Results: On univariate analysis, survival was negatively associated with Karnofsky performance score (KPS) ≤70 (p=0.033), initial N-category ≥1 (p=0.026) and radiation doses given as equivalent dose in 2-Gy fractions (EQD2) <20 Gy. Doses >30 Gy were slightly superior to 20-30 Gy. On multivariate analysis, EQD2 (p=0.015) maintained its significance; a trend was found for N-category (p=0.063) and KPS (p=0.073). Conclusion: Predictors for survival after irradiation of metastases from bladder cancer were identified. Radiation doses ≥20 Gy should be used.