PT  - JOURNAL ARTICLE
AU  - MANIG, LISA
AU  - KÄSMANN, LUKAS
AU  - JANSSEN, STEFAN
AU  - RADES, DIRK
TI  - Predicting Survival After Irradiation of Metastases from Transitional Carcinoma of the Bladder
DP  - 2016 Dec 01
TA  - Anticancer Research
PG  - 6663--6665
VI  - 36
IP  - 12
4099  - http://ar.iiarjournals.org/content/36/12/6663.short
4100  - http://ar.iiarjournals.org/content/36/12/6663.full
SO  - Anticancer Res2016 Dec 01; 36
AB  - Aim: For patients with metastatic bladder cancer, radiotherapy is a good option to control symptoms and improve outcomes. Potential prognostic factors for survival including the radiation dose were investigated. Patients and Methods: Ten factors were evaluated in 63 patients for association with survival after irradiation namely age, gender, performance status, initial T-category, initial N-category, metastases at initial diagnosis, number of metastases, metastatic sites, radiation dose and time from diagnosis of metastases to irradiation. Results: On univariate analysis, survival was negatively associated with Karnofsky performance score (KPS) ≤70 (p=0.033), initial N-category ≥1 (p=0.026) and radiation doses given as equivalent dose in 2-Gy fractions (EQD2) <20 Gy. Doses >30 Gy were slightly superior to 20-30 Gy. On multivariate analysis, EQD2 (p=0.015) maintained its significance; a trend was found for N-category (p=0.063) and KPS (p=0.073). Conclusion: Predictors for survival after irradiation of metastases from bladder cancer were identified. Radiation doses ≥20 Gy should be used.