RT Journal Article SR Electronic T1 Prognostic Factors After Whole-brain Radiotherapy Alone for Brain Metastases from Malignant Melanoma JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 6637 OP 6640 VO 36 IS 12 A1 DIRK RADES A1 LENA SEHMISCH A1 STEFAN JANSSEN A1 STEVEN E. SCHILD YR 2016 UL http://ar.iiarjournals.org/content/36/12/6637.abstract AB Background/Aim: Many patients with brain metastases from melanoma receive whole-brain radiotherapy (WBRT). WBRT-regimens must consider the patient's prognosis in order to deliver the best therapy. Patients and Methods: Seven factors were correlated to intracerebral control and survival after WBRT alone in 92 patients with melanoma: WBRT regimen, age at WBRT, gender, Karnofsky performance score (KPS), number of brain lesions, number of extracranial metastatic sites, and time from melanoma diagnosis to WBRT. Results: On univariate analyses, KPS ≥80 (p=0.075) showed a trend towards improved intracerebral control. Greater WBRT dose (p=0.029), age ≤60 years (p=0.002), KPS ≥80 (p<0.001) and no extracranial site (p=0.008) were positively correlated with survival. On multivariate analyses, KPS (hazard ratio=2.11, 95% confidence interval=1.28-3.47; p=0.003) and number of extracranial metastatic sites (hazard ratio=1.27, 95% confidence interval=1.02-1.56; p=0.030) maintained significance regarding survival. Conclusion: The study identified predictors of survival for patients with melanoma receiving WBRT for brain metastases that can contribute to selection of individualized therapies.