PT - JOURNAL ARTICLE AU - MARGHERITA LUONGO AU - ANNA LISA BRIGIDA AU - LUIGI MASCOLO AU - GENNARO GAUDINO TI - Possible Therapeutic Effects of Ozone Mixture on Hypoxia in Tumor Development DP - 2017 Feb 01 TA - Anticancer Research PG - 425--435 VI - 37 IP - 2 4099 - http://ar.iiarjournals.org/content/37/2/425.short 4100 - http://ar.iiarjournals.org/content/37/2/425.full SO - Anticancer Res2017 Feb 01; 37 AB - Recent literature highlights that ozone therapy could be considered a viable adjuvant therapy in oncological patients receiving radio-chemotherapy. The use of ozone therapy in these patients enhances the action of chemotherapy and at the same time reduces side-effects, such as nausea, vomiting, opportunistic infections, buccal ulcers, hair loss and fatigue. Such positive therapeutic effects of ozone therapy can cause a larger physical and mental wellbeing resulting in improved quality of life. This work reviews the recent acquisition of scientific knowledge regarding the ozone therapy and highlights the molecular and cellular pathways involved.