RT Journal Article SR Electronic T1 mMRI at 3.0 T as an Evaluation Tool of Therapeutic Response to Neoadjuvant CRT in Patients with Advanced-stage Rectal Cancer JF Anticancer Research JO Anticancer Res FD International Institute of Anticancer Research SP 215 OP 222 VO 37 IS 1 A1 ULRIKE I. ATTENBERGER A1 MELISSA M. ONG A1 NILS RATHMANN A1 FABIAN DOYON A1 PETER KIENLE A1 RALF-DIETER HOFHEINZ A1 LOTHAR R. PILZ A1 DIETMAR J. DINTER A1 STEFAN O. SCHOENBERG A1 DANIEL HAUSMANN YR 2017 UL http://ar.iiarjournals.org/content/37/1/215.abstract AB Aim: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. Patients and Methods: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool. Results: Apparent diffusion coefficient values were significantly different among the different tumor RGs before CRT (p=0.041). Changes of dynamic contrast enhanced (DCE) MRI values did not reflect treatment response (PF: p=0.5; MTT: p=0.74). Conclusion: The results of our study population indicate that a high initial apparent diffusion coefficient value may be predictive of response to therapy following CRT.