PT  - JOURNAL ARTICLE
AU  - ULRIKE I. ATTENBERGER
AU  - MELISSA M. ONG
AU  - NILS RATHMANN
AU  - FABIAN DOYON
AU  - PETER KIENLE
AU  - RALF-DIETER HOFHEINZ
AU  - LOTHAR R. PILZ
AU  - DIETMAR J. DINTER
AU  - STEFAN O. SCHOENBERG
AU  - DANIEL HAUSMANN
TI  - mMRI at 3.0 T as an Evaluation Tool of Therapeutic Response to Neoadjuvant CRT in Patients with Advanced-stage Rectal Cancer
DP  - 2017 Jan 01
TA  - Anticancer Research
PG  - 215--222
VI  - 37
IP  - 1
4099  - http://ar.iiarjournals.org/content/37/1/215.short
4100  - http://ar.iiarjournals.org/content/37/1/215.full
SO  - Anticancer Res2017 Jan 01; 37
AB  - Aim: To assess whether multiparametric MRI (mMRI) can serve as a tool for evaluating response to chemoradiation therapy (CRT) in advanced-stage rectal cancer. Patients and Methods: Twenty-one patients underwent a mMRI protocol at 3T before and after CRT. Two experienced radiologists evaluated the MRI measurements and inter-reader correlation was assessed. Changes in functional parameters in relation to regression, as well as pT stage were analyzed. The perfusion parameters plasma flow (PF) and mean transit time (MTT) were calculated offline using the established UMM Perfusion tool. Results: Apparent diffusion coefficient values were significantly different among the different tumor RGs before CRT (p=0.041). Changes of dynamic contrast enhanced (DCE) MRI values did not reflect treatment response (PF: p=0.5; MTT: p=0.74). Conclusion: The results of our study population indicate that a high initial apparent diffusion coefficient value may be predictive of response to therapy following CRT.