TY - JOUR T1 - Pro-inflammatory State Portends Poor Outcomes with Stereotactic Radiosurgery for Brain Metastases JF - Anticancer Research JO - Anticancer Res SP - 5333 LP - 5337 VL - 36 IS - 10 AU - NAREK SHAVERDIAN AU - JASON WANG AU - REBECCA LEVIN-EPSTEIN AU - DORTHE SCHAUE AU - PATRICK KUPELIAN AU - PERCY LEE AU - ISAAC YANG AU - TANIA KAPREALIAN Y1 - 2016/10/01 UR - http://ar.iiarjournals.org/content/36/10/5333.abstract N2 - Aim: We determined if pre-treatment systemic inflammation would predict poor outcomes in the setting of stereotactic radiosurgery (SRS) for brain metastases. Patients and Methods: The pretreatment albumin concentration, neutrophil and lymphocyte counts, and the platelet-to-lymphocyte ratio (PLR) were evaluated to determine association with intracranial control, local control (LC), initial MRI response (MR), and overall survival (OS) among 70 patients with 152 separate brain metastases treated with SRS alone from 2008-2015. Results: On multivariate analysis, a higher neutrophil percentage predicted for poor LC, poor initial MR, poor OS and poor intracranial control (p=0.01, p=0.01, p=0.02 and p=0.03, respectively). A lower percentage of lymphocytes predicted for poor LC and poor MR (p=0.01 and p=0.02), and an elevated PLR predicted for poor OS and poor LC (p=0.05 and p=0.04). Additionally, a lower pretreatment albumin concentration predicted for poor LC and OS (p=0.01 and p=0.03). Conclusion: Pretreatment systemic inflammation is associated with poor outcomes post-SRS. ER -