@article {STRANDBERG6475, author = {SARA STRANDBERG and CAMILLA THELLENBERG KARLSSON and MATTIAS OGREN and JAN AXELSSON and KATRINE RIKLUND}, title = {11C-Acetate-PET/CT Compared to 99mTc-HDP Bone Scintigraphy in Primary Staging of High-risk Prostate Cancer}, volume = {36}, number = {12}, pages = {6475--6479}, year = {2016}, publisher = {International Institute of Anticancer Research}, abstract = {Aim: The aim of this study was to evaluate the detection rate of bone metastases and the added value of 11C-acetate (ACE) positron-emission tomography/computed tomography (PET/CT) compared to bone scintigraphy (BS) in high-risk prostate cancer (PC). Materials and Methods: A total of 66 untreated patients with high-risk PC with ACE-PET/CT and planar BS findings within 3 months of each other were retrospectively enrolled. Findings were compared and verified with follow-up data after an average of 26 months. Results: The rate of detection of bone metastases was superior with ACE-PET/CT compared to BS (p\<0.01). Agreement between the methods and between BS and follow-up was moderate (Cohen{\textquoteright}s kappa coefficient of 0.64 and 0.66, respectively). Agreement between ACE-PET/CT and follow-up was excellent (kappa coefficient of 0.95). Therapy was changed in 11\% of patients due to ACE-PET/CT results. Conclusion: ACE-PET/CT performed better than planar BS in detection of bone metastases in high-risk PC. ACE-PET/CT findings influenced clinical management.}, issn = {0250-7005}, URL = {https://ar.iiarjournals.org/content/36/12/6475}, eprint = {https://ar.iiarjournals.org/content/36/12/6475.full.pdf}, journal = {Anticancer Research} }