RT Journal Article
SR Electronic
T1 Pulsed Electromagnetic Field with Temozolomide Can Elicit an Epigenetic Pro-apoptotic Effect on Glioblastoma T98G Cells
JF Anticancer Research
JO Anticancer Res
FD International Institute of Anticancer Research
SP 5821
OP 5826
VO 36
IS 11
A1 FRANCESCA PASI
A1 LORENZO FASSINA
A1 MARIA EVELINA MOGNASCHI
A1 GIUSEPPE LUPO
A1 FRANCO CORBELLA
A1 ROSANNA NANO
A1 ENRICA CAPELLI
YR 2016
UL http://ar.iiarjournals.org/content/36/11/5821.abstract
AB Treatment with pulsed electromagnetic fields (PEMFs) is emerging as an interesting therapeutic option for patients with cancer. The literature has demonstrated that low-frequency/low-energy electromagnetic fields do not cause predictable effects on DNA; however, they can epigenetically act on gene expression. The aim of the present work was to study a possible epigenetic effect of a PEMF, mediated by miRNAs, on a human glioblastoma cell line (T98G). We tested a PEMF (maximum magnetic induction, 2 mT; frequency, 75 Hz) that has been demonstrated to induce autophagy in glioblastoma cells. In particular, we studied the effect of PEMF on the expression of genes involved in cancer progression and a promising synergistic effect with temozolomide, a frequently used drug to treat glioblastoma multiforme. We found that electromagnetic stimulation in combination with temozolomide can elicit an epigenetic pro-apoptotic effect in the chemo- and radioresistant T98G glioblastoma cell line.